What is 308 excimer laser treatment for vitiligo?
In clinic, 308 excimer laser treatment for vitiligo is very useful and effective for vitiligo treatment. And in many countries, 308 laser treatment is a common therapy for vitiligo. 308nm excimer laser is one kind of excimer laser, meaning Xecl excimer laser. It belongs to continuous pulsed gas laser. The wavelength is during the range of UVB, and the pulse width is usually 10-30 ns.
Nowadays, the causes and pathogenesis of vitiligo are still not clear yet. There are many hypothesis to explain various clinical manifestation of different vitiligo patients.
Why 308nm excimer laser therapy can treat vitiligo?
Its therapy mechanism may be related to T lymphocyte apoptosis. Bian2chi and other people have researched by using immunohistochemical method that 308nm excimer laser can clean up the infiltrative T lymphocyte at lesion positions. Novak and others have researched that 308nm excimer laser can promote the activated T lymphocyte at vitiligo lesion positions apoptosis. The treatment effect is quite obvious, even more obvious than NB-UVB’s ability to cause apoptosis.
After 308 laser irradiation, it can lead to Tlymphocyte apoptosis, thus making the vitiligo lesions disappear not only from naked eye levels, but also making the structures recover to be normal on micro level. Vitiligo is characteristic by selective melanophore, it may relate to patients’ autoimmune response. Narrow band ultraviolet( NB-UVB) may have immunomodulatory effects to make human cells and body fluid generate immunity, which can help to stabilize depigmentation progress. Besides, NB-UVB has been widely identified as similar as PUVA(psoralen photochemical therapy), which can stimulate remained melanophore to gather around peripheral hair follicle outer root sheath. Melanophore can go on mitosis, the generation and movement of melanin, always be induced by various cytokines and inflammatory mediator, including interleukin, tumor necrosis factor α, leukotriene C4. Recent researches indicate that after UVB irradiation, various cytokines and inflammatory mediator will increase, which indicates that this is on mechanism of UVB inducing the restore of melanin.
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Beijing Zhongke Vitiligo Hospital
