Acral lesions of vitiligo are usually resistant to conventional lines of treatment as well as surgical interventions.
We retrospectively analysed data for patients who had undergone non-cultured epidermal cell suspension transplantation for treatment of vitiligo. In total, 36 patients with 80 lesions over acral areas and joints were reviewed: 33 patients had generalized vitiligo, while the remaining three patients had focal vitiligo, and they had been followed up for 6-18 months.
RESULTS:Of the 80 treated lesions, 51 had regained > 75% repigmentation and 23 had regained 50-75% repigmentation. The remaining six lesions, which were all no the distal fingers or toes and the ankle joint, had a poor response.
Vitiligo continues to be an enigmatic disease defying a consensus on the definition and classification. Acrofacial vitiligo (AFV) is currently classified as a form of generalized vitiligo (GV), under non-segmental vitiligo (NSV). However, there is no scientific evidence of these being distinct diseases as they may evolve in time in to generalized vitiligo. AFV can be seen with either a limited involvement of the lips, tips of the fingers/toes and penile shaft as the ‘lip-tip’ form; or, acral vitiligo (AV) in various stages of centripetal progression to the trunk.
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